In 1993, Kenyon’s pioneering discovery that a single-gene mutation could double the lifespan of healthy, fertile C. elegans roundworms sparked an intensive study of the molecular biology of aging. Her findings showed that, contrary to popular belief, aging does not “just happen” in a completely haphazard way. Instead, the rate of aging is subject to genetic control: Animals (and likely people) contain regulatory proteins that affect aging by coordinating diverse collections of downstream genes that together protect and repair the cells and tissues. Kenyon’s findings have led to the realization that a universal hormone-signaling pathway influences the rate of aging in many species, including humans. She has identified many longevity genes and pathways, and her lab was the first to discover that neurons, and also the germ cells, can control the lifespan of the whole animal.
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